Saturday, 14 November 2015

Soon a low cost solution to save animals bitten by rabid dogs in the offing soon

Dear Friends,
                     We are soon going to start experiments to save animals from death due to rabies after being bitten by rabid dogs and mongoose. This would help save the lives of helpless animals usually cows and buffaloes and also save the rural farmers from debt trap.

please wish us good luck for these experiments to be started next year and let me come back to you later next year with results, hopefully positive !

Good Bye

Omesh Bharti

Monday, 31 August 2015

Low cost solution to animal bite victims- life saving for the poor of Asia and Africa is here !

Local infiltration of rabies immunoglobulins without systemic intramuscular administration: An alternative cost effective approach for passive immunization against rabies

Omesh Kumar Bharti Faculty Epidemiologista*, Shampur Narayan Madhusudana Professor of Neurovirology, Headb, Pyare Lal Gaunta Sr.Medical Superintendentc & Ashwin Yajaman BelludiSenior Resident, Neurovirologyd

Presently the dose of rabies immunoglobulin (RIG) which is an integral part of rabies post exposure prophylaxis (PEP) is calculated based on body weight though the recommendation is to infiltrate the wound(s). This practice demands large quantities of RIG which may be un- affordable to many patients. In this background, we conducted this study to know if the quantity and cost of RIG can be reduced by restricting passive immunization to local infiltration alone and avoiding systemic intramuscular administration based on the available scientific evidence. Two hundred and sixty nine category III patients bitten by suspect or confirmed rabid dogs/ animals were infiltrated with equine rabies immunoglobulin (ERIGs) in and around the wound, the quantity of ERIG used was proportionate to the size and number of wounds irrespective of their body weight. They were followed with a regular course of rabies vaccination by intra-dermal route. As against 363 vials of RIGs required for all these cases as per current recommendation based on body weight, they required only 42 vials of 5ml RIG. Minimum dose of RIGs given was 0.25ml and maximum dose given was 8 ml. On an average 1.26 ml of RIGs was required per patient that costs Rs. 150 ($3). All the patients were followed for 9 months and they were healthy and normal at the end of observation period. With local infiltration, that required small quantities of RIG, the RIGs could be made available to all patients in times of short supply in the market. A total of 30 (11%) serum samples of patients were tested for rabies virus neutralizing antibodies by the rapid fluorescent focus inhibition test (RFFIT) and all showed antibody titers >0.5 IU/mL by day 14. In no case the dose was higher than that required based on body weight and no immunosuppression resulted. To conclude, this pilot study shows that local infiltration of RIG need to be considered in times of non availability in the market or un-affordability by poor patients. This preliminary study needs to be done on larger scale in other centers with long term follow up to substantiate the results of our study.
The link; http://www.tandfonline.com/doi/full/10.1080/21645515.2015.1085142#.VeRiU_mqqko

Also other low cost solutions are described in the link below, copy and paste in Google for details;

http://www.scirp.org/journal/PaperInformation.aspx?PaperID=58107

Background: Rabies is a dreaded disease and an estimated 55,000 people die of rabies every year. Himachal Pradesh is in the North bordering China and is predominantly rural and hilly. Villages are near forests, where wild reservoirs of rabies exist. Since health facilities are not accessible easily, we need to innovate on existing schedules of rabies vaccination keeping in view the compliance of the patients and affordability so as to give them the best possible option of treatment. In the year 2006 and 2007, we, at DDU Hospital Shimla, experienced a severe shortage of rabies vaccine and patients were running from pillar to post to fetch rabies vaccine. At the same time, we learnt that some of the patients died because either they were not able to purchase the vaccine, mostly because of its high cost, $35, or they ignored the animal bites and did not seek the treatment. Since last year, we have been experiencing non-availability of rabies immunoglobulins (RIGs) in the market and have to innovate new schedules and techniques to save lives of the patients. Methods: During shortage of rabies vaccine in 2008, we contemplated to start a low cost intra-dermal (ID) clinic so as to make rabies vaccine affordable as intramuscular (IM) vaccination cost five times more than ID vaccination. But, there were three main hurdles. One hurdle was the non-availability of rabies vaccine vials having written on them “For IM/ID use” and another hurdle was only fewer animal bite patients attending the DDU Hospital, sometimes only one or two per day, which was insufficient to open a vaccine vial and distribute among them. The third problem being faced was reluctance of the hospital doctors to prescribe ID vaccine as this was not the practice at higher teaching institutions, including medical colleges. We contacted a vaccine company and few vials labeled as “For IM/ID use” were sourced from Mumbai (1200 km away from here). We asked the Chief Medical Officer, Shimla district to write a letter to all health facilities around our Hospital to give first aid to animal bite patients and then refer them to DDU Hospital for vaccination. Now we were able to pool the patients and divide a single 1 ml vaccine vial among four patients. After continuous advocacy, our stress that WHO has given its approval for ID use of rabies vaccine and that subsequent approval has been granted by Government of India was enough for doctors to prescribe the vaccine as ID. Last Year, we got ethical approval to inject rabies Immunoglobulins (RIGs) only locally in and around the wound at times of scarcity of RIGs in the market. The subsequent follow up of patients proved life saving in crisis of shortage of RIGs. Due to shortage of RIGs we innovatively vaccinated people bitten by rabid dogs or people who had consumed rabid cow’s milk and followed them for outcome, apart from having Rabies Fluorescent Focus Inhibition Test (RFFIT) was done for few of the patiens for verification of protective titers. We innovated a technique of extraction of last drop of vaccine from the vial and also saved a drop of RIGs being used for test dose before giving RIGs to the patients. Results: The first low cost anti-rabies clinic was started on August 2, 2008 after long advocacy sessions with the authorities and the doctors. Since then, we have done many innovations based on local requirements and patients’ feedback and accessibility to treatment. We have given pre and post-exposure prophylaxis to more than 12,000 animal bite victims over more than five years period in this single clinic, saving lives as well as money without any failure even in difficult rabid animal bite cases. Our innovation helped us save the vaccine and immunoglobulins till the last drop. Conclusions: Innovative ways by health providers backed by extensive literature review and scientific evidence can help patients get low cost health deliverables that increase their compliance as medicines/vaccines become affordable to them. Third world countries need to innovate their own ways to solve their problems of scanty resources and find innovative solutions to conquer them, rather than looking elsewhere for solutions.

Thursday, 9 July 2015

What to do in scarce resources to prevent and treat animal bites in India ?
Answer: Copy paste the link below in Google;

http://www.authorstream.com/Presentation/bhartiomesh-2484428-rabies-prophylaxis-scant-resources-hp-may-2015/

Friday, 6 February 2015

my Research papers for benefit of humanity


http://www.scirp.org/journal/articles.aspx?searchCode=Omesh+Kumar+Bharti&searchField=authors&page=1


http://www.scirp.org/journal/articles.aspx?searchCode=Omesh+Kumar+Bharti&searchField=authors&page=1


Sunday, 21 December 2014

My Poems- My Interaction with Life


https://groups.yahoo.com/neo/groups/pha-ncc/files/My%20interaction%20with%20life-Bharti.pdf


https://groups.yahoo.com/neo/groups/pha-ncc/files/My%20interaction%20with%20life-Bharti.pdf

file:///C:/Users/a/Downloads/-My%20interaction%20with%20life-Bharti.pdf

file:///C:/Users/a/Downloads/-My%20interaction%20with%20life-Bharti.pdf

Monday, 8 December 2014

Innovation - Growth Engine for Nation- Book by Dr. Rajiv Dharaska

file:///C:/Users/a/Downloads/Innovation%20Book%20Dr%20Dharaskar.pdf

https://drive.google.com/file/d/0BxI5-ZEkPHT0Y0M3eHpBNDRyREpMV0tyX3hyV0dNRkpJOXVV/view?pli=1


Great job done by Dr. Rajiv Dharaska, my congratulations, copy paste above links on web for book,

With GOD grace, I could complete my dream project, the book namely

Innovation
- Growth Engine for Nation -
Nice Buzzword but Often Misunderstood

(644 pages with 693 References)

In most simplified way, this book explains the Inner Dynamics of the concept of Innovation from A to Z.

To avoid re-registration problem at my website and for the convenience of readers of my book, I am forwarding the PDF file of this book directly through email to all previously registered users (who had downloaded my previous books). In addition to this I am forwarding this book to all my Facebook and LinkedIn contacts.

In USA, Innovation supports at least 40 million jobs and contribute 34.8 % US GDP. South Korea, the Top most Innovative country of the World could raise GDP (PPP) per capita to $33140. India is just at $5410 (123rd position in the world). Innovation is must for economic growth & to become developed nation. But in the Innovation Decade (2011-2020), India slipped 10 ranks (from 66 to 76th position) in Global Innovation Index 2014. How to improve this situation? How to introduce the culture of Innovation in India? What are the root causes of poor Innovation Ecosystem in India? What is the importance of Innovation Clusters? What are the best practices all over the world? How to introduce innovation in industry and R&D labs? How to introduce innovation in Academia? How to enhance employability through Innovation Competencies? I would like to answer these question with the help of hundreds of interesting case studies.

I would like to ignite millions of human brain for innovation through this venture. I am sure once you read few pages of this book, you will be in love with this book. It’s for everybody; from industry to academia; from government authorities to office staff; from parents to students; from faculty of medicine or engineering to faculty of Arts; from small scale businessman to corporate house. I have written this book in such way that everybody should be benefited and start thinking creatively. Before my final departure from this world, I would like to see our nation as Developed Nation. It can happen only through Innovation.

I am sure, after “Skill India” and “Make in India” the next slogan will be “Innovation India”.

If you like this book then
  • Convey your valuable suggestion and comments to me at rajiv.dharaskar@gmail.com
  • Please help me to circulate this book among all educated persons related to academics (Engineering, Medicine, Management, Law, Pharmacy, Arts, and Commerce), Industry, Government Authorities, IT Professionals, Politicians, Decision Makers, Parents, and Students of every discipline.


Jai Hind

Dr. Rajiv Dharaskar
Ph.D. (Computer Engineering)
Director MPGI Group of Institutes Integrated Campus


Dr. Rajiv Dharaskar
Ph.D.(Computer Engg.),M.Tech.(Comp.),M.Phil, M.Sc., DCS,
Director,
MPGI Group of Institutes Integrated Campus, Nanded
 
Mobile : +91 7507777501,  8087979393

Saturday, 11 October 2014

Helping make rabies immunoglobulins affordable to poor- experiments for low cost



http://www.slideee.com/slide/omesh-when-rabies-immunoglobulins-are-not-available-not-affordable


http://www.slideee.com/slide/omesh-when-rabies-immunoglobulins-are-not-available-not-affordable